Cushing’s disease must first be distinguished from Cushing’s syndrome, which can be caused by a variety of conditions, including the long-term use of steroid medications like prednisone, prescribed for chronic conditions such as asthma, arthritis or bowel disorders.
Cushing’s disease most commonly results from the overproduction of adrenocorticotrophic hormone (ACTH) by the pituitary gland at the base of the brain. This excessive ACTH production stimulates the adrenal glands, located above the kidneys, to produce excessive amounts of cortisol, a steroid hormone.
Symptoms of cortisol excess may include fatigue, weakness, depression, mood swings, increased thirst and urination, and loss of menstrual periods. Physical signs may include weight gain, especially on the abdomen, face, neck and upper back, weakness of the muscles of the upper arms and legs, thinning of the skin with easy bruising and the appearance of pink or purple stretch marks, increase in acne and facial hair, thinning of scalp hair and elevated blood pressure. Surgical treatment results in a cure more than 80 percent of the time.
As you can see, Cushing’s disease is a very complex disorder, and it’s important that all your questions be answered. Make a list to bring to your next doctor’s visit.
Posted 4-10-02
